Abstract Septic Shock and Vasopressor Therapy: The Impact of Excessive Mean Arterial
Pressure Values Barbara Clark Mims, PhD Director: Nalini Jairath, PhD, MSc. N., RN …

Purpose Mean arterial pressure (MAP) reflects the adequacy of tissue perfusion. In septic
shock, vasopressors are recommended to target MAP≥ 65 mmHg. The impact of chronic …

Introduction It is unclear to which level mean arterial blood pressure (MAP) should be
increased during septic shock in order to improve outcome. In this study we investigated the …

Background The optimal approach to titrate vasopressor therapy is unclear. Recent sepsis
guidelines recommend a mean arterial pressure (MAP) target of 65 mmHg and higher for …

Guidelines recommend that a mean arterial pressure (MAP) value greater than 65 mm Hg
should be the initial blood pressure target in septic shock, but what evidence is there to …

After years and years of consensus expert opinion as to mean arterial pressure (MAP) target
and vasopressor choice in septic shock management, literature is now emerging that …

Physicians often prescribe vasopressors to correct pathological vasodilation and improve
tissue perfusion in patients with septic shock, but the evidence to inform practice on …

Purpose Guidelines for shock recommend mean arterial pressure (MAP) targets for
vasopressor therapy of at least 65 mmHg and, until recently, suggested that patients with …

Background Without robust clinical evidence to guide titration of vasopressors in septic
shock, it is unclear how dosing of these potent medications occurs. We sought to measure …

Purpose In shock, hypotension may contribute to inadequate oxygen delivery, organ failure
and death. We conducted the Optimal Vasopressor Titration (OVATION) pilot trial to inform …