Filamentous fungi usually refer to the eukaryotic microorganisms with developed mycelia
and without large fruiting bodies. Filamentous fungi not only play an important role in …

Background Gene editing using CRISPR/Cas9 is a widely used tool for precise gene
modification, modulating gene expression and introducing novel proteins, and its use has …

Advances in genetic transformation techniques have made important contributions to
molecular genetics. Various molecular tools and strategies have been developed for …

Actinobacteria are one of the most important sources of pharmaceutically valuable and
industrially relevant secondary metabolites. Modern genome mining reveals that the …

Background CRISPR/Cas9-based genome editing is quickly becoming a powerful tool
within the field of fungal genetics. Adaptation of CRISPR/Cas9 systems are allowing for …

Basidiomycetes can produce various valuable secondary metabolites with bioactivities.
However, the low titer of metabolites has greatly limited their application. Currently, shortage …

Filamentous fungi are prolific producers of bioactive natural products and play a vital role in
drug discovery. Yet, their potential cannot be fully exploited since many biosynthetic genes …

The implementation of Agrobacterium tumefaciens as a transformation tool revolutionized
approaches to discover and understand gene functions in a large number of fungal species …

Aspergillus fumigatus is a saprophytic fungal pathogen that is the cause of more than
300,000 life-threatening infections annually. Our understanding of pathogenesis and factors …

Marine-derived Aspergillus terreus produces a variety of structurally novel secondary
metabolites, most of which show unique biological activities. However, the lack of efficient …