Aquaporin-4 dysregulation in a controlled cortical impact injury model of posttraumatic epilepsy
JI Szu, S Chaturvedi, DD Patel, DK Binder - Neuroscience, 2020 - Elsevier
Posttraumatic epilepsy (PTE) is a long-term negative consequence of traumatic brain injury
(TBI) in which recurrent spontaneous seizures occur after the initial head injury. PTE …
(TBI) in which recurrent spontaneous seizures occur after the initial head injury. PTE …
Modulation of posttraumatic epileptogenesis in aquaporin‐4 knockout mice
JI Szu, DD Patel, S Chaturvedi, JW Lovelace… - …, 2020 - Wiley Online Library
Objective To determine the role of aquaporin‐4 (AQP4) in posttraumatic epileptogenesis
using long‐term video‐electroencephalographic (vEEG) recordings. Here, differences in …
using long‐term video‐electroencephalographic (vEEG) recordings. Here, differences in …
Aquaporin-4 reduces post-traumatic seizure susceptibility by promoting astrocytic glial scar formation in mice
Seizures are important neurological complications after traumatic brain injury (TBI) and are
reported for up to 50% of patients with TBI. Despite several studies, no drug strategy has …
reported for up to 50% of patients with TBI. Despite several studies, no drug strategy has …
Decreased hemispheric Aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats
The cerebral Aquaporin-4 (AQP4) water channel is suggested to be involved in brain edema
formation aggravated by reduced cerebral blood flow early after traumatic brain injury (TBI) …
formation aggravated by reduced cerebral blood flow early after traumatic brain injury (TBI) …
Deletion of aquaporin-4 is neuroprotective during the acute stage of micro traumatic brain injury in mice
F Liang, C Luo, G Xu, F Su, X He, S Long, H Ren… - Neuroscience …, 2015 - Elsevier
Micro traumatic brain injury (TBI) is the most common type of brain injury, but the
mechanisms underlying it are poorly understood. Aquaporin-4 (AQP4) is a water channel …
mechanisms underlying it are poorly understood. Aquaporin-4 (AQP4) is a water channel …
Fluid-percussion brain injury induces changes in aquaporin channel expression
AA Oliva Jr, Y Kang, JS Truettner, J Sanchez-Molano… - Neuroscience, 2011 - Elsevier
Edema, the accumulation of excess fluid, is a major pathological change in the brain that
contributes significantly to pathology and mortality after moderate to severe brain injury …
contributes significantly to pathology and mortality after moderate to severe brain injury …
Aquaporin-4 is a potential drug target for traumatic brain injury via aggravating the severity of brain edema
A Xiong, R Xiong, J Yu, Y Liu, K Liu, G Jin, J Xu… - Burns & …, 2021 - academic.oup.com
Background Traumatic brain edema (TBE) is caused by a specific water channel mediated
by membrane aquaporins. Aquaporin-4 (AQP4) plays an especially important role in this …
by membrane aquaporins. Aquaporin-4 (AQP4) plays an especially important role in this …
'Hit & Run'model of closed-skull traumatic brain injury (TBI) reveals complex patterns of post-traumatic AQP4 dysregulation
Cerebral edema is a major contributor to morbidity associated with traumatic brain injury
(TBI). The methods involved in most rodent models of TBI, including head fixation, opening …
(TBI). The methods involved in most rodent models of TBI, including head fixation, opening …
Effect of penetrating brain injury on aquaporin-4 expression using a rat model
CJ Neal, EY Lee, A Gyorgy, JM Ecklund… - Journal of …, 2007 - liebertpub.com
Cerebral edema (CE) is a frequent and potentially lethal consequence of various
neurotraumas, including penetrating brain injury (PBI). Aquaporin-4 (AQP4) water channel is …
neurotraumas, including penetrating brain injury (PBI). Aquaporin-4 (AQP4) water channel is …
Aquaporin-4-dependent edema clearance following status epilepticus
We investigated the role of aquaporin-4 in the development of cerebral edema following
kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques …
kainic acid-induced status epilepticus (SE) using specific gravimetry and T2 MRI techniques …