The fourth generation (G4) of poly (amidoamine) dendrimer was PEGylated and then
physically incorporated with carboplatin to develop the new drug delivery carrier. The proton …

Cell penetrating peptides (CPP) have the ability to penetrate the cell membrane and have
been associated with various cargos for their facile intracellular translocation. The current …

Dendrimers were well-known as a polymeric nanoparticle drug carrier system. Among them,
polyamidoamine (PAMAM) dendrimers were firstly and systematically studied. Herein, to …

Dendrimer, a new class of hyper-branched polymer with predetermined molecular weight
and well-controlled size, has received much attention in nanobiomedical applications such …

Polyamidoamine (PAMAM) dendrimers are extensively researched as potential drug
delivery system thanks to their desirable features such as controlled and stable structures …

Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering
anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of …

Carboplatin (CAR) is a second generation platinum-based compound emerging as one of
the most widely used anticancer drugs to treat a variety of tumors. In an attempt to address …

Because of the synergistic effects of drugs and minimal drug dose for cancer therapy,
combination chemotherapy is frequently used in the clinic. In this study, hyaluronic acid …

Polymer mediated drug delivery system represents a novel promising platform for tumor-
targeting with reduced systemic side effects and improved chemotherapeutical efficacy. In …

Objective: Cisplatin has limited clinical applications due to drug resistance. PAMAM
dendrimer was chosen as a vehicle to counteract cisplatin-resistance and its mechanism …