Abstract Aims High chromogranin-A (CgA) levels were observed in patients with heart failure
but its source remained uncertain. We evaluated whether CgA is produced by myocardium …

Background In chronic heart failure, several hormonal systems are activated with diagnostic
and prognostic implications. We tested the hypotheses that serum Chromogranin-A (CgA) …

Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular
diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an …

Background—Chromogranin B (CgB) is a member of the granin protein family. Because
CgB is often colocalized with chromogranin A (CgA), a recently discovered cardiac …

Chromogranin A (CgA), a major component of the chromaffin granules, is co-stored and co-
released with catecholamines. It is also expressed in extra-adrenal sites, including the heart …

Background—Chromogranin A (CgA) levels have previously been found to predict mortality
in heart failure (HF), but currently no information is available regarding CgA processing in …

In this study we tested the hypothesis that vasostatins could act as myocardial modulators in
the mammalian heart. Using the Langendorff–perfused rat heart, the cardiac effects of the …

Chromogranin A (CGA), produced by human and rat myocardium, generates several
biologically active peptides processed at specific proteolytic cleavage sites. A highly …

Aims To assess the association between circulating levels of chromogranin A (CgA) and
outcome in a large population of patients with chronic heart failure (HF). Methods and results …

Over the last 50 years, increasing evidence has documented the ability of cardiac non-
neuronal cells to synthesize and release catecholamines (CAs) and the vasorelaxant …