Cancer immunotherapy, including immune checkpoint blockade and CAR-T cell therapy,
has introduced revolutionary approaches to treating patients with cancer. The success and …

Modulation of the tumor microenvironment is becoming an increasingly popular research
topic in the field of immunotherapy, and studies regarding immune checkpoint blockades …

Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …

Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint
inhibitors as especially promising candidates for cancer therapy. However, some issues …

Simple Summary Immune checkpoint inhibitors (ICIs) constitute a paradigm shift in cancer
therapy, and it has greatly expanded our knowledge of anticancer immunity and has …

With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of
care in cancer management has evolved rapidly. However, immunotherapy is not currently …

The immune cells within the tumor microenvironment (TME) play important roles in
tumorigenesis. It has been known that these tumor associated immune cells may possess …

Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …

Highlights•Tumors exaggerate and exploit natural immunosuppressive and tolerogenic
mechanisms.•This milieu favors angiogenesis and tissue remodeling but is suppressive for T …

The tumor microenvironment (TME) is a complex, dynamic battlefield for both immune cells
and tumor cells. The advent of the immune checkpoint inhibitors (ICI) since 2011, such as …