Key players of the immunosuppressive tumor microenvironment and emerging therapeutic strategies
K Park, MS Veena, DS Shin - Frontiers in cell and developmental …, 2022 - frontiersin.org
The tumor microenvironment (TME) is a complex, dynamic battlefield for both immune cells
and tumor cells. The advent of the immune checkpoint inhibitors (ICI) since 2011, such as …
and tumor cells. The advent of the immune checkpoint inhibitors (ICI) since 2011, such as …
[HTML][HTML] Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling
KB Nguyen, S Spranger - The Journal of cell biology, 2020 - ncbi.nlm.nih.gov
The development of cancer immunotherapies has been guided by advances in our
understanding of the dynamics between tumor cells and immune populations. An emerging …
understanding of the dynamics between tumor cells and immune populations. An emerging …
Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation
T Yaguchi, Y Kawakami - International immunology, 2016 - academic.oup.com
Although recent cancer immunotherapy strategies, including immune-checkpoint blockade
(ie blocking PD-1, PD-L1 or CTLA-4), have shown durable clinical effects in some (but not …
(ie blocking PD-1, PD-L1 or CTLA-4), have shown durable clinical effects in some (but not …
Recent advances and challenges in cancer immunotherapy
C Peterson, N Denlinger, Y Yang - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy helps a person's immune system to target tumor cells.
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …
Cancer plasticity and the microenvironment: Implications for immunity and therapy response
Over the last decade, our understanding of how cancer cells interact with their
microenvironment has grown exponentially. It has become evident that a complex interplay …
microenvironment has grown exponentially. It has become evident that a complex interplay …
Beyond cDC1: emerging roles of DC crosstalk in cancer immunity
R Noubade, S Majri-Morrison, KV Tarbell - Frontiers in immunology, 2019 - frontiersin.org
Dendritic cells (DCs) efficiently process and present antigens to T cells, and by integrating
environmental signals, link innate and adaptive immunity. DCs also control the balance …
environmental signals, link innate and adaptive immunity. DCs also control the balance …
Dendritic cells: behind the scenes of T-cell infiltration into the tumor microenvironment
V Lucarini, O Melaiu, P Tempora, S D'Amico… - Cancers, 2021 - mdpi.com
Simple Summary High T-cell infiltration has been associated with improved clinical
outcomes in many human solid tumors. However, these cells are not autonomous in their …
outcomes in many human solid tumors. However, these cells are not autonomous in their …
Immune checkpoint blockade immunotherapy to activate anti‐tumour T‐cell immunity
AG Ramsay - British journal of haematology, 2013 - Wiley Online Library
The tumour microenvironment plays a dual role in cancer: it can promote tumour
progression by establishing pro‐tumour survival conditions but can also suppress tumour …
progression by establishing pro‐tumour survival conditions but can also suppress tumour …
Cancer immunotherapy by targeting immune checkpoints: mechanism of T cell dysfunction in cancer immunity and new therapeutic targets
HF Tsai, PN Hsu - Journal of biomedical science, 2017 - Springer
Immune checkpoints or coinhibitory receptors, such as cytotoxic T lymphocyte antigen
(CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses …
(CTLA)-4 and programmed death (PD)-1, play important roles in regulating T cell responses …
Evolving strategies for tumor immunotherapy: enhancing the enhancer and suppressing the suppressor
Y Gu, Y Liu, X Cao - National Science Review, 2017 - academic.oup.com
Cancers develop complex and dynamic tissue microenvironments to support their sustained
growth, invasion and metastasis. For decades, rapid progress has been made in the cross …
growth, invasion and metastasis. For decades, rapid progress has been made in the cross …