Chronic kidney disease (CKD) is characterized by inflammation, injury and fibrosis.
Dysregulated innate immune responses mediated by macrophages play critical roles in …

Macrophages are heterogenous cells of the innate immune system that can fluidly modulate
their phenotype to respond to their local microenvironment. They are found throughout the …

Macrophage accumulation associates closely with the degree of renal structural injury and
renal dysfunction in human kidney diseases. Depletion of macrophages reduces while …

Background: Glomerular and interstitial macrophage infiltration is a feature for both the acute
and chronic kidney diseases. Macrophages have been shown to play a diverse role in …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …

Macrophages are found in normal kidney and in increased numbers in diseased kidney,
where they act as key players in renal injury, inflammation, and fibrosis. Macrophages are …

Kidney macrophages are central in kidney disease pathogenesis and have therapeutic
potential in preventing tissue injury and fibrosis. Recent studies highlighted that kidney …

Inflammation, a process intimately linked to renal disease, can be defined as a complex
network of interactions between renal parenchymal cells and resident immune cells, such as …

Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules
released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby …

Macrophage-targeted therapies hold potential for limiting kidney injury and hypertension. To
realize this potential, future studies will be required to understand precise mechanisms in …