Objectives With disease-modifying drugs on the horizon for degenerative ataxias,
ecologically valid motor biomarkers are highly warranted. In this observational study, we …

With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid,
finely granulated, digital health measures are highly warranted to augment clinical and …

Abstract Background Cerebellar Ataxias are a group of gait disorders resulting from
dysfunction of the cerebellum, commonly characterised by slowly progressing incoordination …

An appropriate biomarker for spinocerebellar degeneration (SCD) has not been identified.
Here, we performed gait analysis on patients with pure cerebellar type SCD and assessed …

Measures of step variability and body sway during gait have shown to correlate with clinical
ataxia severity in several cross‐sectional studies. However, to serve as a valid progression …

Background Quantitative assessment of severity of ataxia‐specific gait impairments from
wearable technology could provide sensitive performance outcome measures with high face …

Background. Patients suffering from cerebellar ataxia have extremely variable gait kinematic
features. We investigated whether and how wearable inertial sensors can describe the gait …

Instrumental gait analysis is increasingly recognized as a useful tool for the evaluation of
movement disorders. The various assessment devices available to date have mostly been …

Background Clinical and regulatory acceptance of upcoming molecular treatments in
degenerative ataxias might greatly benefit from ecologically valid endpoints that capture …

Background Spinocerebellar ataxia type 6 (SCA6) is an inherited ataxia with no established
treatment. Gait ataxia is a prominent feature causing substantial disability. Understanding …