Over three million infections were reported in the United States of America in 2019. These
infections were caused by either antibiotic-resistant pathogens or Clostridioides difficile and …

The discovery and clinical utilization of antibiotics is one of the most important
breakthroughs that has revolutionized medical science and significantly contributed to …

As of 1 July 2018, a total of 48 antibiotics (including combinations) and 10 biologicals that
target the WHO priority pathogens, Mycobacterium tuberculosis and Clostridium difficile …

The discovery of penicillin marked the beginning of the golden era of antibiotics. Antibiotics
have been the valuable weapons combating an array of bacterial infections. However, each …

Bacterial resistance to existent antibiotherapy is a perpetual internationally-recognized
problem. Year after year, there is a continuous need for novel antibacterial drugs and this …

There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

Drug repurposing is a safe and successful pathway to speed up the novel drug discovery
and development processes compared with de novo drug discovery approaches. Drug …

In recent decades, the development of resistance and the selection of pathogens has
become a global drama that has made it necessary to place the rational use of existing …

There is a pressing need to develop novel antimicrobials to circumvent the scourge of
antimicrobial resistance. The objective of this study is to identify non-antibiotic drugs with …