Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet
factors dictating the balance between innate and adaptive anti-tumor immunity are unclear …

Background While stimulator of interferon genes (STING) activation in innate immune cells
of the tumor microenvironment can result in CD8 T cell-dependent antitumor immunity …

A major subset of human cancers shows evidence for spontaneous adaptive immunity,
which is reflected by the presence of infiltrating CD8+ T cells specific for tumor antigens …

Background Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor
immunity against immunogenic tumors in mice, prompting clinical trials to test STING …

The aberrant appearance of DNA in the cytoplasm triggers the activation of cGAS-cGAMP-
STING signaling and induces the production of type I interferons, which play critical roles in …

Cancer immunotherapy with immune checkpoint inhibitors has achieved unprecedented
success in cancer treatment; However, only a subset of patients achieved clinical benefit …

T cells that recognize tumor antigens are crucial for mounting antitumor immune responses.
Induction of antitumor T cells in immunogenic tumors depends on STING, the intracellular …

Cytosolic DNA sensing is an important process during the innate immune response that
activates the stimulator of interferon genes (STING) adaptor and induces IFN-I. STING incites …

The fact that a subset of human cancers showed evidence for a spontaneous adaptive
immune response as reflected by the T cell‐inflamed tumor microenvironment phenotype …

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are
required for the function of STING (TMEM173), an ER-resident transmembrane protein …