Approval summary: cetuximab in combination with cisplatin or carboplatin and 5‐fluorouracil for the first‐line treatment of patients with recurrent locoregional or …

MH Cohen, H Chen, S Shord, C Fuchs, K He… - The …, 2013 - academic.oup.com
Abstract Learning Objectives Compare survival outcomes among patients with SCCHN
treated with a platinum/5‐FU regimen with and without cetuximab. Compare adverse event …

[HTML][HTML] Platinum-based chemotherapy plus cetuximab in head and neck cancer

JB Vermorken, R Mesia, F Rivera… - … England Journal of …, 2008 - Mass Medical Soc
Background Cetuximab is effective in platinum-resistant recurrent or metastatic squamous-
cell carcinoma of the head and neck. We investigated the efficacy of cetuximab plus …

[HTML][HTML] Translating KEYNOTE-048 into practice recommendations for head and neck cancer

P Szturz, JB Vermorken - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
In 2016, immune checkpoint inhibitors entered the therapeutic portfolio of squamous cell
carcinoma of the head and neck (SCCHN) in the second-line recurrent and/or metastatic …

Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic …

JB Vermorken, J Trigo, R Hitt, P Koralewski… - Journal of clinical …, 2007 - ascopubs.org
Purpose To evaluate the efficacy and safety of the epidermal growth factor receptor–directed
monoclonal antibody cetuximab administered as a single agent in patients with recurrent …

A prospective real-world multi-center study to evaluate progression-free and overall survival of radiotherapy with cetuximab and platinum-based chemotherapy with …

M Hecht, D Hahn, P Wolber, MG Hautmann, D Reichert… - Cancers, 2021 - mdpi.com
Simple Summary Despite recent developments in immune checkpoint inhibitors, the
treatment of locoregionally recurrent head and neck squamous cell cancer (HNSCC) …

Cetuximab therapy for patients with advanced squamous cell carcinomas of the head and neck

WN William Jr, ES Kim, RS Herbst - Nature Reviews Clinical Oncology, 2009 - nature.com
We discuss the results of the phase III EXTREME (Erbitux in First-Line Treatment of
Recurrent or Metastatic Head and Neck Cancer) trial. In this study, 442 untreated patients …

Paradigm change in first-line treatment of recurrent and/or metastatic head and neck squamous cell carcinoma

E Borcoman, G Marret, C Le Tourneau - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapy has made a breakthrough in the treatment of patients with
recurrent and/or metastatic head and neck squamous cell carcinoma in the second line …

[HTML][HTML] Survival predictors and outcomes of patients with recurrent and/or metastatic head and neck cancer treated with chemotherapy plus cetuximab as first-line …

F Pontes, AR Garcia, I Domingues, MJ Sousa… - Cancer Treatment and …, 2021 - Elsevier
Background In patients with recurrent or metastatic head and neck squamous cell carcinoma
(R/M HNSCC) the estimated prognosis is usually poor. Patient-specific factors that affect …

Advances in the management of recurrent or metastatic squamous cell carcinoma of the head and neck

DM Shin, FR Khuri - Head & neck, 2013 - Wiley Online Library
Most patients with locally advanced squamous cell carcinoma of the head and neck
(SCCHN) undergo definitive therapy, yet locoregional recurrence and metastasis are …

Clinical outcomes of platinum-based chemotherapy plus cetuximab for recurrent or metastatic squamous cell carcinoma of the head and neck: comparison between …

H Sato, K Tsukahara, I Okamoto, Y Katsube… - Acta Oto …, 2019 - Taylor & Francis
Background: Combination therapy consisting of a platinum agent, 5-fluorouracil and
cetuximab (EXTREME regimen) is recommended for recurrent or metastatic squamous cell …