NAAA-regulated lipid signaling governs the transition from acute to chronic pain
Chronic pain affects 1.5 billion people worldwide but remains woefully undertreated.
Understanding the molecular events leading to its emergence is necessary to discover …
Understanding the molecular events leading to its emergence is necessary to discover …
NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice
Y Fotio, A Mabou Tagne, E Squire, H Lee… - Nature …, 2024 - nature.com
Circulating monocytes participate in pain chronification but the molecular events that cause
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …
their deployment are unclear. Using a mouse model of hyperalgesic priming (HP), we show …
N-acylethanolamine acid amidase (NAAA), a new path to unleash PPAR-mediated analgesia
BK Taylor - Pain, 2013 - journals.lww.com
The nuclear receptor superfamily includes retinoid, thyroid hormone, steroid and
peroxisome proliferator-activated (PPAR) receptors. Unlike plasma membrane receptors that …
peroxisome proliferator-activated (PPAR) receptors. Unlike plasma membrane receptors that …
Genetic blockade of NAAA cell-specifically regulates fatty acid ethanolamides (FAEs) metabolism and inflammatory responses
N-Acylethanolamine acid amidase (NAAA) is a lysosomal enzyme responsible for the
hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs …
hydrolysis of fatty acid ethanolamides (FAEs). However, the role of NAAA in FAEs …
Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception
JZ Long, AM Roche, CA Berdan… - Proceedings of the …, 2018 - National Acad Sciences
N-acyl amino acids (NAAs) are a structurally diverse class of bioactive signaling lipids
whose endogenous functions have largely remained uncharacterized. To clarify the …
whose endogenous functions have largely remained uncharacterized. To clarify the …
[HTML][HTML] NAPE-PLD regulates specific baseline affective behaviors but is dispensable for inflammatory hyperalgesia
I Chen, LB Murdaugh, C Miliano, Y Dong… - Neurobiology of Pain, 2023 - Elsevier
Abstract N-acyl-ethanolamine (NAEs) serve as key endogenous lipid mediators as revealed
by manipulation of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for …
by manipulation of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for …
Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition
The intracellular lipid amidases, fatty acid amide hydrolase (FAAH) and N-acylethanolamine
acid amidase (NAAA), terminate the actions of anandamide and palmitoylethanolamide …
acid amidase (NAAA), terminate the actions of anandamide and palmitoylethanolamide …
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
C Solorzano, C Zhu, N Battista… - Proceedings of the …, 2009 - National Acad Sciences
Identifying points of control in inflammation is essential to discovering safe and effective
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …
antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid …
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase
Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of
anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH …
anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH …
Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism
The lysosomal cysteine hydrolase N-acylethanolamine acid amidase (NAAA) deactivates
palmitoylethanolamide (PEA), a lipid-derived PPAR-α agonist that is critically involved in the …
palmitoylethanolamide (PEA), a lipid-derived PPAR-α agonist that is critically involved in the …