Recent developments of organoids engineering and organ-on-a-chip microfluidic
technologies have enabled the recapitulation of the major functions and architectures of …

Chemotherapy is one of the most effective cancer treatments. Starting from the discovery of
new molecular entities, it usually takes about 10 years and 2 billion US dollars to bring an …

Simple Summary Organoids, also known as self-organized 3D organ-like clusters, represent
almost a physiological system for studying cells, stem cells, tissues, and diseases, especially …

The development of vascular networks in microfluidic chips is crucial for the long-term
culture of three-dimensional cell aggregates such as spheroids, organoids, tumoroids, or …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

The transition to increasingly sophisticated microfluidic systems has led to the emergence of
“organ-on-chip” technology that can faithfully recapitulate organ-level function. Given the …

Highlights•Several viable methods currently exist to create vascularized in vitro
tissues.•Progress has been made in developing systems that mimic specific organs or …

In vitro cell culture models are emerging as promising tools to understand human
development, disease progression, and provide reliable, rapid and cost-effective results for …

Most cancer treatment strategies target cell proliferation, angiogenesis, migration, and
intravasation of tumor cells in an attempt to limit tumor growth and metastasis. An in vitro …

Tumors develop in intricate microenvironments required for their sustained growth, invasion,
and metastasis. The tumor microenvironment plays a critical role in the malignant or drug …