Progress of delivery methods for CRISPR-Cas9

W Yang, J Yan, P Zhuang, T Ding, Y Chen… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Gene therapy is becoming increasingly common in clinical practice, giving hope
for the correction of a wide range of human diseases and defects. The CRISPR/Cas9 …

[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges

M Behr, J Zhou, B Xu, H Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …

[HTML][HTML] Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing

S Zhang, J Shen, D Li, Y Cheng - Theranostics, 2021 - ncbi.nlm.nih.gov
CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications

C Liu, L Zhang, H Liu, K Cheng - Journal of controlled release, 2017 - Elsevier
The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

L Li, S Hu, X Chen - Biomaterials, 2018 - Elsevier
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas
(CRISPR-associated) genome editing systems have become one of the most robust …

[HTML][HTML] Recent advances in the delivery and applications of nonviral CRISPR/Cas9 gene editing

F Sinclair, AA Begum, CC Dai, I Toth… - Drug delivery and …, 2023 - Springer
The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 genome
editing system has been a major technological breakthrough that has brought revolutionary …

Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field

ZY He, K Men, Z Qin, Y Yang, T Xu, YQ Wei - Science China Life Sciences, 2017 - Springer
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein
9 (CRISPR-Cas9) system provides a novel genome editing technology that can precisely …

Delivery of CRISPR/Cas9 by novel strategies for gene therapy

L Wang, W Zheng, S Liu, B Li, X Jiang - ChemBioChem, 2019 - Wiley Online Library
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …

[HTML][HTML] CRISPR-Cas9 for in vivo gene therapy: Promise and hurdles

WJ Dai, LY Zhu, ZY Yan, Y Xu, QL Wang… - Molecular Therapy-Nucleic …, 2016 - cell.com
Owing to its easy-to-use and multiplexing nature, the genome editing tool CRISPR-Cas9
(clustered regularly interspaced short palindromic repeats (CRISPR) associated nuclease 9) …

Delivery of CRISPR/Cas9 for therapeutic genome editing

X Xu, T Wan, H Xin, D Li, H Pan, J Wu… - The journal of gene …, 2019 - Wiley Online Library
The clustered, regularly‐interspaced, short palindromic repeat (CRISPR)‐associated
nuclease 9 (CRISPR/Cas9) is emerging as a promising genome‐editing tool for treating …