Objectives Treatment of difficult-to-treat (D2T) RA patients is generally based on trial-and-
error and can be challenging due to a myriad of contributing factors. We aimed to identify …

Objectives Patients with difficult-to-treat rheumatoid arthritis (RA) remain symptomatic
despite treatment according to current European League Against Rheumatism (EULAR) …

Objectives The aim of this study was to investigate the clinical characteristics of patients with
difficult-to-treat RA (D2T RA) and the usefulness of switching to drugs with different modes of …

Objective To develop evidence-based European Alliance of Associations for Rheumatology
(EULAR) points to consider (PtCs) for the management of difficult-to-treat rheumatoid …

Background Despite treatment according to the current management recommendations, a
significant proportion of patients with rheumatoid arthritis (RA) remain symptomatic. These …

The European Alliance of Associations for Rheumatology recently defined difficult to treat
(D2T) rheumatoid arthritis (RA) and provided points to consider in its management. This …

Objectives To summarise, by a systematic literature review (SLR), the evidence regarding
pharmacological and non-pharmacological therapeutic strategies in difficult-to-treat …

Increased effectiveness of pharmacological treatments in early RA has led many to believe
that difficult-to-treat, established RA is a condition of the past. However, there are still plenty …

Management of RA patients has significantly improved over the past decades. However, a
substantial proportion of patients is difficult-to-treat (D2T), remaining symptomatic after …

Objective To investigate whether patients with RA enrolled in randomized controlled trials
(RCTs) and observational studies may differ in terms of characteristics that could modify …