When activated by increase in intracellular Ca 2+, anoctamins (TMEM16 proteins) operate
as phospholipid scramblases and as ion channels. Anoctamin 1 (ANO1) is the Ca 2+ …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Since the discovery of TMEM16A (anoctamin 1, ANO1) as Ca 2+-activated Cl− channel, the
protein was found to serve different physiological functions, depending on the type of tissue …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …

Summary Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl−
channels transiently activated by an increase in intracellular Ca2+. These channels are …

Fluid and electrolyte releasing from secretory epithelia are elaborately regulated by
orchestrated activity of ion channels. The activity of chloride channel at the apical membrane …

Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in
great detail with respect to structure and function, but much less is known about the other …

Anoctamins (ANOs) are multifunctional membrane proteins that consist of 10 homologs.
ANO1 (TMEM16A) and ANO2 (TMEM16B) are anion channels activated by intracellular …

The calcium-activated chloride channel anoctamin1 (ANO1; TMEM16A) is fundamental for
the function of epithelial organs. Mice lacking ANO1 expression exhibit transport defects and …

The TMEM16 family of membrane proteins, also known as anoctamins, plays key roles in a
variety of physiological functions that range from ion transport to phospholipid scrambling …