Recent reports suggest declines in the age-specific risk of Alzheimer's dementia in higher
income Western countries. At the same time, investigators believe that worldwide trends of …

The distinction between Alzheimer's disease and vascular dementia, the two most common
types of dementia, has been undermined by recent advances in epidemiologic, clinical …

The involvement of vascular factors in Alzheimer dementia was first appreciated over 100
years ago. Recently, significant advances in our understanding of these brain‐vascular …

Alzheimer's disease (AD) biomarkers and stroke risk factors independently predict cognitive
impairment, likely through independent disease pathways. However, limited work has …

Vascular factors are now established risk factors for cognitive decline, both for dementia and
its two main subtypes: Alzheimer's disease (AD) and vascular dementia. Their impact likely …

Introduction The impact of cardiovascular risk burden on brain pathologies remains unclear.
We aimed to examine the association of the Framingham General Cardiovascular Risk …

Background Macrostructural brain alterations in the form of brain atrophy or cortical thinning
typically occur during the prodromal Alzheimer's disease stage. Mixed findings largely …

Background: Decedents with late-life dementia are often found at autopsy to have vascular
pathology, cortical Lewy bodies, hippocampal sclerosis, and/or TDP-43 encephalopathy …

Advances in epidemiological, clinical, imaging, and neuropathological studies have
undermined the clear distinction between vascular and Alzheimer-type dementia, which has …

Background: Vascular factors are recognized as important risk factors for Alzheimer's
disease, although it is unknown whether these factors directly lead to the typical …