Roles of vascular risk factors in the pathogenesis of dementia

S Takeda, H Rakugi, R Morishita - Hypertension Research, 2020 - nature.com
The number of people with dementia is rapidly growing along with the aging of society and
is becoming a social issue worldwide. The results of recent clinical and basic studies have …

Associations among vascular risk factors, neuroimaging biomarkers, and cognition: preliminary analyses from the Multi‐Ethnic Study of Atherosclerosis (MESA)

SN Lockhart, CL Schaich, S Craft… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Little is known about how antecedent vascular risk factor (VRF) profiles impact
late‐life brain health. Methods We examined baseline VRFs, and cognitive testing and …

Does vascular burden contribute to the progression of mild cognitive impairment to dementia?

F Clerici, B Caracciolo, I Cova… - Dementia and geriatric …, 2012 - karger.com
Aims: To investigate the contribution of vascular risk factors (VRFs), vascular diseases (VDs)
and white matter lesions (WMLs) to the progression of mild cognitive impairment (MCI) to …

Alzheimer's disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

PT Nelson, E Head, FA Schmitt, PR Davis… - Acta …, 2011 - Springer
Human studies are reviewed concerning whether “aging”-related mechanisms contribute to
Alzheimer's disease (AD) pathogenesis. AD is defined by specific neuropathology: neuritic …

Midlife vascular risk factors and Alzheimer's disease: evidence from epidemiological studies

AM Tolppanen, A Solomon… - Journal of …, 2012 - content.iospress.com
The shared risk factor profile between cardiovascular diseases and Alzheimer's disease
(AD), observations on vascular pathology in AD, and altered cerebral blood flow in AD …

Dementia, stroke, and vascular risk factors; a review

R Sahathevan, A Brodtmann… - International Journal of …, 2012 - journals.sagepub.com
Interest in dementia has increased over the past few decades. Stroke is an important cause
of cognitive problems. The term vascular cognitive impairment is now used to describe …

Vascular risk factors: a ticking time bomb to Alzheimer's disease

JC de la Torre - American Journal of Alzheimer's Disease & …, 2013 - journals.sagepub.com
Evidence is growing that vascular risk factors (VRFs) for Alzheimer's disease (AD) affect
cerebral hemodynamics to launch a cascade of cellular and molecular changes that initiate …

Breakdown of the cerebrovasculature and blood-brain barrier: a mechanistic link between diabetes mellitus and Alzheimer's disease

EL Goldwaser, NK Acharya, A Sarkar… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) and diabetes mellitus (DM) are among the most pervasive and
devastating disorders that afflict people throughout the world. Although typically associated …

The influence of vascular risk factors on cognitive decline in patients with dementia: a systematic review

K Blom, MH Emmelot-Vonk, HDL Koek - Maturitas, 2013 - Elsevier
Background and objective Vascular risk factors (VRF) are associated with a higher
incidence of dementia. However, the relationship with disease progression is unclear. This …

The links between cardiovascular diseases and Alzheimer's disease

J Leszek, EV Mikhaylenko, DM Belousov… - Current …, 2021 - ingentaconnect.com
The root cause of non-inherited Alzheimer's disease (AD) remains unknown despite
hundreds of research studies performed to attempt to solve this problem. Since proper …