The renal microcirculation plays a major role in the delivery of blood and oxygen to the
kidney. In sepsis, alterations in renal microvascular perfusion, in conjunction with increased …

The pathogenesis of sepsis-associated acute kidney injury is complex and likely involves
perfusion alterations, a dysregulated inflammatory response, and bioenergetic …

Despite identification of several cellular mechanisms being thought to underlie the
development of septic acute kidney injury (AKI), the pathophysiology of the occurrence of …

Knowledge of the pathophysiological mechanisms of acute kidney injury emphasizes the
importance of the role of the microcirculation in its development. Preventive and therapeutic …

Acute kidney injury (AKI) remains one of the main causes of morbidity and mortality in the
intensive care medicine today. Its pathophysiology and progress to chronic kidney disease …

Traditionally, renal ischemia has been regarded as central to the pathogenesis of sepsis-
associated acute kidney injury (SA-AKI). Accordingly, hemodynamic management of SA-AKI …

Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Acute kidney injury (AKI) is a rapidly developing condition often associated with critical
illness, with a high degree of morbidity and mortality, whose pathophysiology is ill …

Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …