Present research aim was to identify functional tests in semen associated with DNA damage
and chromatin maturity (protamination) which predict the outcome in assisted reproduction …

The exchange of histones with protamines in sperm DNA results in sperm chromatin
compaction and protection. Variations in sperm protamine expression are associated with …

The aim of this study was to evaluate the relationship between the protamine ratio (P1/P2),
DNA fragmentation of spermatozoa and protamine deficiency. Patients were grouped into …

Objectives: The present study aimed to measure the protamines P1 and P2 concentrations,
standard sperm parameters, and also DNA fragmentation and condensation. In addition, the …

Existing literature suggests evidence that protamine deficiency is related to DNA damage
and male fertility. In this meta‐analysis, we analyzed the relationship between the ratio of …

Sperm protamine deficiency has been associated with human male infertility. However, most
studies have adopted a global approach to assessing sperm protamine levels. Thus, it is not …

SUMMARY Protamine 1 (PRM1) and 2 (PRM2) are major nuclear proteins in spermatozoa
known to bind to chromatin during early spermatogenesis. The aim of this study was to …

Abstract Objective Abnormality in Histone-Protamine replacements has been indicated to
cause sperm DNA damage and infertility. The aim of the present study was to investigate the …

OBJECTIVE: To evaluate whether aberrant sperm P1/P2 ratios are predictive of abnormal
fertilizing ability and are related to in vitro fertilization (IVF) outcome. DESIGN: Prospective …

STUDY QUESTION Could the protamine-1 to protamine-2 mRNA ratio serve as a biomarker
to estimate the fertilizing capacity of sperm from men taking part in an IVF/ICSI programme …