Background Inhalation of chemotherapeutic drugs directly into the lungs augments the drug
exposure to lung cancers. The inhalation of free drugs however results in over exposure and …

Lung cancer is the most malignant cancer today; in order to develop an effective drug
delivery system for lung cancer therapy, gelatin nanoparticles (GPs) were modified with …

Molecularly targeted therapy emerged as a novel therapeutic strategy in the treatment of
multiple cancers. In the present study, we have developed gemcitabine (GEM)-loaded …

To develop a polymer-anticancer drug conjugate, we employed gelatin nanoparticles (GPs)
as carriers of cisplatin (CDDP) with anticipated improved therapeutic effect and reduced side …

Introduction This study aims to develop a novel co-delivery gefitinib and quercetin system
loaded with PLGA-PEG nanoparticles and evaluate their antitumor activity in vitro and in …

Combinations of two potent chemotherapeutic drugs are often used to treat early stage lung
cancer. To enhance the efficiency of the treatment, a combinational co-drug delivery system …

Inhalation administration, compared with intravenous administration, significantly enhances
chemotherapeutic drug exposure to the lung tissue and may increase the therapeutic effect …

Most anticancer drugs often fail in clinical trials due to poor solubility, poor bioavailability,
lack of targeted delivery and several off-target effects. Polymeric nanoparticles such as poly …

Since lung cancer is the most malignant cancer today, a specific drug-delivery system has
been developed for superior outcome. In this study, gelatin nanoparticles (GPs) employed …

Chemotherapy is the primary treatment for advanced non-small-cell lung cancer (NSCLC).
However, related dose-dependent toxicity limits its clinical use. Therefore, it is necessary to …