Methylated ctDNA quantification: non-invasive approach to monitoring hepatocellular carcinoma burden

I Angeli-Pahim, A Chambers, S Duarte… - Journal of the …, 2023 - journals.lww.com
Background: Non-invasive, precision monitoring of hepatocellular carcinoma (HCC)
treatment efficacy would greatly facilitate personalized therapy and improve patient …

Discovery and clinical validation of cost-effective noninvasive early detection of hepatocellular carcinoma (HCC) through circulating tumor DNA (ctDNA) methylation …

XR Yang, R Liu, J Zhou, J Fan, DZ Guo, A Huang… - 2022 - ascopubs.org
4103 Background: Hepatocellular carcinoma (HCC) is one of the most common and lethal
cancers worldwide, especially in Asian counties. Patients can be treated more effectively if …

Methylated circulating tumor DNA in hepatocellular carcinoma: A comprehensive analysis of biomarker potential and clinical implications

Q Zhu, J Xie, W Mei, C Zeng - Cancer Treatment Reviews, 2024 - Elsevier
The intricate epigenetic landscape of hepatocellular carcinoma (HCC) is profoundly
influenced by alterations in DNA methylation patterns. Understanding these alterations is …

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

R Xu, W Wei, M Krawczyk, W Wang, H Luo, K Flagg… - Nature materials, 2017 - nature.com
An effective blood-based method for the diagnosis and prognosis of hepatocellular
carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying …

Circulating free methylated tumor DNA markers for sensitive assessment of tumor burden and early response monitoring in patients receiving systemic chemotherapy …

JS Bhangu, A Beer, M Mittlböck, D Tamandl… - Annals of …, 2018 - journals.lww.com
Background: Neoadjuvant chemotherapy (neoCTx) followed by hepatic resection is the
treatment of choice for patients with colorectal cancer liver metastasis (CLM). Treatment …

Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study

DZ Guo, A Huang, YC Wang, S Zhou… - Clinical and …, 2024 - Wiley Online Library
Background Early diagnosis of hepatocellular carcinoma (HCC) can significantly improve
patient survival. We aimed to develop a blood‐based assay to aid in the diagnosis, detection …

Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors

T Draškovič, N Zidar, N Hauptman - Cancers, 2023 - mdpi.com
Simple Summary Malignant liver tumors consist of primary tumors and metastases. A correct
diagnosis can be achieved with different methods; one of them is the analysis of the cell-free …

Utilization of personalized tumor-specific methylation haplotypes of circulating DNA to monitor minimal residual disease in patients with hepatocellular carcinoma …

XR Yang, DZ Guo, SY Zhang, MJ Xu, H Chen, CC Ma… - 2024 - ascopubs.org
e16245 Background: Minimal residual disease (MRD) is considered an essential factor
leading to early relapse after radical surgery, which is challenging to be detected by …

Genome-wide plasma cell-free DNA methylation profiling to identify high-performing biomarkers for early detection of hepatocellular carcinoma.

XR Yang, A Huang, Y Wang, J Peng, R Jiang, Z Li… - 2020 - ascopubs.org
4600 Background: Hepatocellular carcinoma (HCC) represents the second most common
cause of cancer deaths worldwide.□-fetoprotein (AFP) is the most common serological test …

Early detection of molecular residual disease and risk stratification for stage I to III colorectal cancer via circulating tumor DNA methylation

S Mo, L Ye, D Wang, L Han, S Zhou, H Wang… - JAMA …, 2023 - jamanetwork.com
Importance Detection of molecular residual disease and risk stratification as early as
possible may improve the treatment of patients with cancer. Efficient pragmatic tests are …