[HTML][HTML] Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis

EA Catton, DA Bonsor, C Herrera… - nature …, 2023 - nature.com
Life-threatening bacterial infections in women after childbirth, known as puerperal sepsis,
resulted in classical epidemics and remain a global health problem. While outbreaks of …

[HTML][HTML] CEACAM1 recognition by bacterial pathogens is species-specific

M Voges, V Bachmann, R Kammerer, U Gophna… - BMC microbiology, 2010 - Springer
Background Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), an
immunoglobulin (Ig)-related glycoprotein, serves as cellular receptor for a variety of Gram …

Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptors

NM van Sorge, DA Bonsor, L Deng, E Lindahl… - The EMBO …, 2021 - embopress.org
Streptococcus agalactiae, also known as group B Streptococcus (GBS), is the major cause
of neonatal sepsis in humans. A critical step to infection is adhesion of bacteria to epithelial …

[HTML][HTML] Extracellular IgC2 Constant Domains of CEACAMs Mediate PI3K Sensitivity during Uptake of Pathogens

M Voges, V Bachmann, J Naujoks, K Kopp, CR Hauck - PloS one, 2012 - journals.plos.org
Background Several pathogenic bacteria utilize receptors of the CEACAM family to attach to
human cells. Binding to different members of this receptor family can result in uptake of the …

CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens

S Pils, DT Gerrard, A Meyer, CR Hauck - International Journal of Medical …, 2008 - Elsevier
Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) is an
immunoglobulin-related glycoprotein exclusively expressed on granulocytes. In contrast to …

[HTML][HTML] Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa

P Muenzner, A Kengmo Tchoupa, B Klauser… - PLoS …, 2016 - journals.plos.org
Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface
of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are …

Specific binding to differentially expressed human carcinoembryonic antigen-related cell adhesion molecules determines the outcome of Neisseria gonorrhoeae …

EA Islam, VC Anipindi, I Francis… - Infection and …, 2018 - Am Soc Microbiol
The gonococcal Opa proteins are an antigenically variable family of surface adhesins that
bind human carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) …

[HTML][HTML] Adaptation to host-specific bacterial pathogens drives rapid evolution of a human innate immune receptor

J Adrian, P Bonsignore, S Hammer, T Frickey… - Current Biology, 2019 - cell.com
The selective pressure by infectious agents is a major driving force in the evolution of
humans and other mammals. Members of the carcinoembryonic antigen-related cell …

The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase‐dependent pathway

H Sarantis, SD Gray‐Owen - Cellular microbiology, 2007 - Wiley Online Library
The human‐restricted pathogens Neisseria gonorrhoeae, Neisseria meningitidis,
Haemophilus influenzae and Moraxella catarrhalis colonize host tissues via …

HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens

A Buntru, A Roth, NJ Nyffenegger-Jann… - Archives of biochemistry …, 2012 - Elsevier
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to the
immunoglobulin superfamily and contribute to cell–cell adhesion and signal modulation in …