Investigation into novel gut-microbiome mediated pathways in cardiovascular disease

S Esposito - 2022 - figshare.le.ac.uk
Dietary metabolism is increasingly implicated in the regulation of cardiovascular disease
and there is intense focus on understanding this relationship. The bacterial flora, which …

[HTML][HTML] TMAO: how gut microbiota contributes to heart failure

Y Zhang, Y Wang, B Ke, J Du - Translational Research, 2021 - Elsevier
An increasing amount of evidence reveals that the gut microbiota is involved in the
pathogenesis and progression of various cardiovascular diseases. In patients with heart …

A gut microbiome metabolite paradoxically depresses contractile function while activating mitochondrial respiration

S Naghipour, JJ Fisher, AV Perkins… - Disease Models & …, 2023 - journals.biologists.com
ABSTRACT Trimethylamine-N-oxide (TMAO) is an end-product of gut microbiome
metabolism linked to cardiovascular disease (CVD). However, precise cardiovascular …

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

WHW Tang, SL Hazen - Translational Research, 2017 - Elsevier
There is increasing appreciation that changes in microbiome composition and function can
promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites …

[HTML][HTML] Microbiota-derived metabolite trimethylamine N-oxide protects mitochondrial energy metabolism and cardiac functionality in a rat model of right ventricle heart …

M Videja, R Vilskersts, S Korzh, H Cirule… - Frontiers in cell and …, 2021 - frontiersin.org
Aim: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite synthesized in
host organisms from specific food constituents, such as choline, carnitine and betaine …

Dietary metabolism, the gut microbiome, and heart failure

WHW Tang, DY Li, SL Hazen - Nature Reviews Cardiology, 2019 - nature.com
Advances in our understanding of how the gut microbiota contributes to human health and
diseases have expanded our insight into how microbial composition and function affect the …

[HTML][HTML] Trimethylamine N-oxide in cardiovascular disease

RA Konieczny, W Kuliczkowski - Advances in Clinical and …, 2022 - advances.umw.edu.pl
Although traditional cardiovascular risk factors are well established and understood,
mortality and morbidity in patients with cardiovascular disease (CVD) remains high …

[HTML][HTML] Targeting TMAO and its metabolic pathway for cardiovascular diseases treatment

Z Hoseini-Tavassol, S Hasani-Ranjbar - Journal of Diabetes & Metabolic …, 2021 - Springer
Given the prevalence of cardiovascular diseases (CVDs), as one of the most important non-
communicable diseases (NCDs), the recognition of diagnostic biomarkers and potential …

[HTML][HTML] Gut Microbial Metabolite Trimethylamine-N-Oxide and Its Role in Cardiovascular Diseases

S Barik, A Mukherjee, AJ Kolady… - … and Treatments for …, 2022 - intechopen.com
Atherosclerosis (AS) is the common pathological underpinning of numerous cardiovascular
illnesses (CVDs), and it is the leading cause of death worldwide. In recent years …

Gut microbiota–a new companion on the path of cardiovascular diseases progression: surprising roles of long-time neighbors

OM Drapkina, AN Kaburova - Rational pharmacotherapy in …, 2016 - rpcardio.elpub.ru
The last decade is marked by the significant reinterpretation of the gut microbiota
contribution to chronic disease progression. The researchers' careful attention is focused on …