Background: While amyotrophic lateral sclerosis (ALS) is widely recognised as a multi-
network disorder with extensive frontotemporal and cerebellar involvement, sensory …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting primarily the
motor system, but in which extra‐motor manifestations are increasingly recognized. The loss …

Primary lateral sclerosis (PLS) is a disorder of progressive upper motor neuron dysfunction,
in the absence of clinical signs of lower motor neuron involvement or family history …

A standardised imaging protocol was implemented to evaluate disease burden in specific
thalamic and amygdalar nuclei in 133 carefully phenotyped and genotyped motor neuron …

Increased interest in the underlying pathogenesis of primary lateral sclerosis (PLS) and its
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …

Background Primary lateral sclerosis (PLS) is a progressive upper motor neuron
neurodegenerative condition. The diagnosis is made using clinical history, objective …

Magnetic resonance imaging measures have been proposed as objective markers to study
upper motor neuron loss in motor neuron disorders. Cross-sectional studies have identified …

Background Although only a few frontotemporal lobar degeneration (FTLD) patients develop
frank amyotrophic lateral sclerosis (ALS), motor neuron dysfunctions (MNDys) occur in a …

Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

Background Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease
characterized by both upper and lower motor neuron degeneration. While neuroimaging …