Pulmonary fibrosis is characterised by excessive scarring in the lung which leads to
compromised lung function, serious breathing problems and in some diseases, death. It …

Extracellular matrix microenvironment contributes actively t... : Current Opinion in Pulmonary
Medicine Extracellular matrix microenvironment contributes actively to pulmonary fibrosis …

The composition and mechanical properties of the extracellular matrix are dramatically
altered during the development and progression of pulmonary fibrosis. Recent evidence …

Lung fibrosis is characterized by the continuous accumulation of extracellular matrix (ECM)
proteins produced by apoptosis-resistant (myo) fibroblasts. Lung epithelial injury promotes …

Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by
excessive scarring, which leads to increased tissue stiffness, loss in lung function and …

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung
disease characterized by irreversible fibrosis. Current disease pathogenesis assumes an …

Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides
physical support to tissues and is essential for normal organ function. In the lung, ECM plays …

The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …

This review discusses the role of extracellular matrix (ECM) quality in the pathogenesis of
pulmonary fibrosis (PF). In PF, the highly ordered structure of collagens and elastin within …

Connective tissue remodeling of the interstitium is an important feature of chronic lung
diseases encompassing interstitial inflammatory changes and subsequent pulmonary …