An organism requires a range of biomolecules for its growth. By definition, these are
essential molecules which constitute the basic metabolic requirements of an organism. A …

Mycobacterium tuberculosis causes more deaths in humans than any other bacterial
pathogen. The most recent data from the World Health Organization reveal that over 9 …

Tuberculosis remains a major health problem due to the emergence of drug-resistant strains
of Mycobacterium tuberculosis. Some models have provided valuable information about …

OBJECTIVE: To establish the critical test concentrations for seven second-line anti-
tuberculosis drugs in the Bactec Mycobacterial Growth Indicator Tube (MGIT) 960 TB system …

Animal models have an important role in the preclinical evaluation of new antituberculosis
drug candidates. Although it does not recapitulate the clinicopathological manifestations of …

Despite the low expensive and effective four-drug treatment regimen (isoniazid, rifampicin,
pyrazinamide and ethambutol) was introduced 40 years ago, TB continues to cause …

The reliability of the Mycobacteria Growth Indicator Tube (MGIT) 960 system for rapid
antimicrobial susceptibility testing (AST) of Mycobacterium tuberculosis was evaluated. Forty …

Tuberculosis (TB) continues to pose a serious global health threat, and the current vaccine,
BCG, has variable efficacy. However, the development of a more effective vaccine is …

Objectives Lead antituberculosis (anti-TB) molecules with novel mechanisms of action are
urgently required to fuel the anti-TB drug discovery pipeline. The aim of this study was to …

Development of an improved vaccine against tuberculosis (TB) is hindered by the lack of a
surrogate of protection. Efficacy of new TB vaccines in humans can only be evaluated by …