Type VII secretion systems are membrane-embedded nanomachines used by Gram-positive
bacteria to export effector proteins from the cytoplasm to the extracellular environment. Many …

Bacterial type VIIb secretion systems (T7SSb) are multisubunit integral membrane protein
complexes found in Firmicutes that play a role in both bacterial competition and virulence by …

The type III secretion system (T3SS) is employed by a number of Gram-negative bacterial
pathogens to inject toxins into eukaryotic cells. The biogenesis of this complex machinery …

Mycobacterial pathogens use specialized type VII secretion (T7S) systems to transport
crucial virulence factors across their unusual cell envelope into infected host cells. These …

Bacteria have been constantly competing for nutrients and space for billions of years. During
this time, they have evolved many different molecular mechanisms by which to secrete …

Gram-positive bacteria deploy the type VII secretion system (T7SS) to facilitate interactions
between eukaryotic and prokaryotic cells. In recent work, we identified the TelC protein from …

Bacteria deliver toxic effectors via type VI secretion systems (T6SSs) to dominate
competitors, but the identity and function of many effectors remain unknown. Here we …

The type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in
pathogenic mycobacteria. All T7SS substrate proteins described to date share a common …

Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic
bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes …

Abstract Type VII secretion (T7S) systems are specialized machineries used by
mycobacterial pathogens to transport important virulence factors across their highly …