CRISPR/Cas9 delivery system engineering for genome editing in therapeutic applications

H Cheng, F Zhang, Y Ding - Pharmaceutics, 2021 - mdpi.com
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) systems have emerged as a robust and versatile genome editing platform …

[HTML][HTML] CRISPR/Cas9 systems: delivery technologies and biomedical applications

Y Du, Y Liu, J Hu, X Peng, Z Liu - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
The emergence of the clustered regularly interspaced short palindromic repeats
(CRISPR)/CRISPR-associated protein 9 (Cas9) genome-editing system has brought about a …

CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

HX Wang, M Li, CM Lee, S Chakraborty… - Chemical …, 2017 - ACS Publications
Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …

Delivery of CRISPR/Cas9 by novel strategies for gene therapy

L Wang, W Zheng, S Liu, B Li, X Jiang - ChemBioChem, 2019 - Wiley Online Library
Precise editing of the genome of a living body is a goal pursued by scientists in many fields.
In recent years, CRISPR (clustered regularly interspaced short palindromic repeat)/Cas …

[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges

M Behr, J Zhou, B Xu, H Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …

[HTML][HTML] Principles of CRISPR-Cas9 technology: advancements in genome editing and emerging trends in drug delivery

AAA Aljabali, M El-Tanani, MM Tambuwala - Journal of Drug Delivery …, 2024 - Elsevier
The rapid advancement of CRISPR-Cas9 technology has instigated a profound
transformation in genome editing with significant implications for fields like health …

Non-viral and viral delivery systems for CRISPR-Cas9 technology in the biomedical field

ZY He, K Men, Z Qin, Y Yang, T Xu, YQ Wei - Science China Life Sciences, 2017 - Springer
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein
9 (CRISPR-Cas9) system provides a novel genome editing technology that can precisely …

Delivery of CRISPR/Cas9 for therapeutic genome editing

X Xu, T Wan, H Xin, D Li, H Pan, J Wu… - The journal of gene …, 2019 - Wiley Online Library
The clustered, regularly‐interspaced, short palindromic repeat (CRISPR)‐associated
nuclease 9 (CRISPR/Cas9) is emerging as a promising genome‐editing tool for treating …

Synthetic multi-layer nanoparticles for CRISPR-Cas9 genome editing

H Tang, X Zhao, X Jiang - Advanced drug delivery reviews, 2021 - Elsevier
The clustered regularly interspaced short palindromic repeat (CRISPR) has great potential
to revolutionize biomedical research and disease therapy. The specific and efficient genome …

Delivering the CRISPR/Cas9 system for engineering gene therapies: Recent cargo and delivery approaches for clinical translation

RA Foley, RA Sims, EC Duggan, JK Olmedo… - … in Bioengineering and …, 2022 - frontiersin.org
Clustered Regularly Interspaced Short Palindromic Repeats associated protein 9
(CRISPR/Cas9) has transformed our ability to edit the human genome selectively. This …