Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical
ventilation of uninjured lungs is unknown. Objectives: To test the hypotheses that a strategy …

Background Mechanical ventilation with variable tidal volumes (VT) may improve lung
function and reduce ventilator-induced lung injury in experimental acute respiratory distress …

Background Improperly set mechanical ventilation (MV) with normal lungs can advance lung
injury and increase the incidence of acute respiratory distress syndrome (ARDS). A key …

Neutrophils are considered to play a central role in ventilator-induced lung injury (VILI).
However, the pulmonary consequences of neutrophil accumulation have not been fully …

Objectives: Prone positioning is frequently used during acute respiratory distress syndrome.
However, mechanisms by which it improves oxygenation are poorly understood, as well as …

Purpose Imaging of acute lung inflammation is pivotal to evaluate innovative ventilation
strategies. We aimed to develop and validate a three-tissue compartment kinetic model …

Background. Mechanical ventilation (MV) has the potential to initiate ventilator‐induced lung
injury (VILI). The pathogenesis of VILI has been primarily studied in animal models using …

Introduction The benefits of prone position ventilation are well demonstrated in the severe
forms of acute respiratory distress syndrome, but not in the milder forms. We investigated the …

Background Vigorous spontaneous effort can potentially worsen lung injury. This study
hypothesized that the prone position would diminish a maldistribution of lung stress and …

Purpose Ventilator-induced lung injury (VILI) is a recognized complication of mechanical
ventilation. Although the specific mechanism by which mechanical ventilation causes lung …