Measurement of alveolar volume (Va) and regional ventilation (V̇a) is crucial to
understanding the pathophysiology of acute lung injury and ventilator-induced lung injury …

Objectives: To determine the effect on compartmentalization of the tumor necrosis factor
(TNF)-α response in the lung and systemically after ventilation with high peak inspiratory …

Mechanical ventilation is an important part of medical care in intensive care units and
operating rooms to support respiration. While it is a critical component of medical care, it is …

PET is a versatile imaging tool for physiologic investigation. By imaging the regional effects
of interventions commonly performed in critically ill patients with ALI, PET has improved our …

Ventilator‐induced lung injury (VILI) is the phenomenon by which mechanical ventilation
exacerbates lung injury in critically ill patients. It is particularly relevant for those suffering …

Rationale: Positive end-expiratory pressure (PEEP) and prone positioning may induce lung
recruitment and affect alveolar dynamics in acute respiratory distress syndrome (ARDS) …

Activated neutrophils contribute to the development of ventilator-induced lung injury (VILI)
caused by high-pressure mechanical ventilation. However, exact cellular and molecular …

Background Ventilator-induced lung injury (VILI) is a clinical complication of mechanical
ventilation observed in patients with acute respiratory distress syndrome. It is characterized …

Background An on-going debate exists as to whether partial ventilatory support is lung
protective in an acute phase of ARDS. So far, the effects of different respiratory efforts on the …

Prone positioning is an established treatment for severe acute lung injury conditions.
Neuronal dysfunction frequently occurs with mechanical ventilation-induced acute lung …