Cytotoxic, or helper T cells recognize antigen via T cell receptors (TCRs) that can see their
target antigen as short sequences of peptides bound to the groove of proteins of major …

Loading of classical major histocompatibility complex (MHC) class II molecules with antigen-
derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro …

Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

T cell antigen receptors (TCRs) expressed on cytotoxic or helper T cells can only see their
specific target antigen as short sequences of peptides bound to the groove of proteins of …

Peptide binding to classical major histocompatibility complex (MHC) class II molecules is
known to be determined by the properties of the class ii peptide binding groove but recently …

Considerable progress has been made in the field of major histocompatibility complex
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …

Introduction 3. MHC class II synthesis and assembly with chaperones 4. Biochemical and
structural characterization of DM 5. The molecular mechanism of DM function 5.1 …

MHC II proteins present processed antigens to CD4+ T cells through a complex set of events
and players that include chaperons and accessory molecules. Antigen processing …

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

T cells bearing αβ receptors recognize antigenic peptides bound to class I and class II
glycoproteins encoded in the major histocompatibility complex (MHC). Cytotoxic and helper …