The generation of functional sperm relies on spermatogonial stem cells (SSCs) as they can
maintain a stem cell pool for continuous generation of functional spermatozoa. The …

Mammalian spermatogenesis is a classic adult stem cell–dependent process, supported by
self-renewal and differentiation of spermatogonial stem cells (SSCs). Studying SSCs …

The maintenance of spermatogonial stem cells (SSCs) provides the foundation for life-long
spermatogenesis. Although glial-cell-line-derived neurotrophic factor and fibroblast growth …

Proper regulation of spermatogonial stem cells (SSCs) is crucial for sustaining steady-state
spermatogenesis. Previous work has identified several paracrine factors involved in this …

Fibroblast growth factor 2 (FGF2) and glial cell line-derived neurotrophic factor (GDNF) are
required to recapitulate spermatogonial stem cell (SSC) self-renewal in vitro. Although …

This review discusses how recent methodological developments that have facilitated study
of spermatogonial stem cells (SSCs) in vitro and in vivo have been used in conjunction with …

Spermatogonial stem cells (SSCs) reside within the stem cell niche along the basement
membrane of the seminiferous tubules in the testis, and their actions provide the basis for …

Spermatogonial stem cells (SSCs) capable of self-renewal and differentiation are the
foundation for spermatogenesis. Although several factors important for these processes …

The long-term production of billions of spermatozoa relies on the regulated proliferation and
differentiation of spermatogonial stem cells (SSCs). To date only a few factors are known to …

Spermatogenesis originates from self-renewal of spermatogonial stem cells (SSCs).
Previous studies have reported conflicting roles of gonadotropic pituitary hormones in SSC …