Development and evaluation of oleanolic acid dosage forms and its derivatives

A Feng, S Yang, Y Sun, L Zhang… - BioMed Research …, 2020 - Wiley Online Library
Oleanolic acid is a pentacyclic triterpenoid compound that exists widely in medicinal herbs
and other plants. Because of the extensive pharmacological activity, oleanolic acid has …

Recent advances in medicinal chemistry of oleanolic acid derivatives

YH Yang, SY Dai, FH Deng, LH Peng, C Li, YH Pei - Phytochemistry, 2022 - Elsevier
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …

[HTML][HTML] Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases

TB Ayeleso, MG Matumba, E Mukwevho - Molecules, 2017 - mdpi.com
The increasing demand for natural products as an alternative therapy for chronic diseases
has encouraged research into the pharmacological importance of bioactive compounds from …

Oleanolic acid

J Pollier, A Goossens - Phytochemistry, 2012 - Elsevier
Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound
with a widespread occurrence throughout the plant kingdom. In nature, the compound exists …

Oleanolic acid derivatives for pharmaceutical use: A patent review

C Lin, X Wen, H Sun - Expert opinion on therapeutic patents, 2016 - Taylor & Francis
Introduction: Oleanolic acid belongs to the pentacyclic triterpene family. In China, oleanolic
acid has been used as an over the counter (OTC) hepatoprotective drug for decades …

Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometry

M Song, T Hang, Y Wang, L Jiang, X Wu… - … of pharmaceutical and …, 2006 - Elsevier
A highly selective and sensitive HPLC–ESI–MS–MS method was developed for the
determination of oleanolic acid in human plasma. The oleanolic acid and glycyrrhetinic acid …

A review on recent developments in the anticancer potential of oleanolic acid and its analogs (2017-2020)

N Gupta - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Oleanolic acid (OA) is a pentacyclic triterpenoid class of natural products that possess a
broad range of biological activities, specifically anticancer activities. Considering the …

[HTML][HTML] Oleanolic acid: Extraction, characterization and biological activity

JM Castellano, S Ramos-Romero, JS Perona - Nutrients, 2022 - mdpi.com
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

Dual strategies to improve oral bioavailability of oleanolic acid: Enhancing water-solubility, permeability and inhibiting cytochrome P450 isozymes

Q Jiang, X Yang, P Du, H Zhang, T Zhang - European Journal of …, 2016 - Elsevier
Oleanolic acid (OA) is a typical BCS IV drug with low water-solubility and poor permeability,
metabolized by cytochrome P450 (CYP) isozymes in the intestinal tract, such as CYP3A …

[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …