The mammalian genome encodes thousands of long non-coding RNAs (lncRNAs), many of
which are developmentally regulated and differentially expressed across tissues, suggesting …

Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …

Successful heart development depends on the careful orchestration of a network of
transcription factors and signaling pathways. In recent years, in vitro cardiac differentiation …

Large intergenic non-coding RNAs (lincRNAs) play widespread roles in epigenetic
regulation during multiple differentiation processes, but little is known about their mode of …

Human protein-coding genes are often accompanied by divergently transcribed non-coding
RNAs whose functions, especially in cell fate decisions, are poorly understood. Using an …

The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the
activation state of genes controlling pluripotency, lineage commitment, and cell …

The blueprints of developing organs are preset at the early stages of embryogenesis.
Transcriptional and epigenetic mechanisms are proposed to preset developmental …

The blueprints for developing organs are preset at the early stages of embryogenesis.
Transcriptional and epigenetic mechanisms are proposed to preset developmental …

The multiphasic regulation of the Wnt/β-catenin canonical pathway is essential for
cardiogenesis in vivo and in vitro. To achieve tight regulation of the Wnt/β-catenin signaling …

Transcriptional programming plays a key role in determining the cell state. Timely
reconfiguration of chromatin structure and attenuation of pluripotent genes are required for …