The porcine innate immune system: an update

KH Mair, C Sedlak, T Käser, A Pasternak… - Developmental & …, 2014 - Elsevier
Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …

The piglet as a model for B cell and immune system development

JE Butler, KM Lager, I Splichal, D Francis… - Veterinary immunology …, 2009 - Elsevier
The ability to identify factors responsible for disease in all species depends on the ability to
separate those factors which are environmental from those that are intrinsic. This is …

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

L Fairbairn, R Kapetanovic, DP Sester… - Journal of leukocyte …, 2011 - academic.oup.com
The biology of cells of the mononuclear phagocyte system has been studied extensively in
the mouse. Studies of the pig as an experimental model have commonly been consigned to …

The pig as a model for immunology research

R Pabst - Cell and tissue research, 2020 - Springer
The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …

Development of Dog Immune System: From in Uterus to Elderly

M Pereira, A Valério-Bolas, C Saraiva-Marques… - Veterinary …, 2019 - mdpi.com
Immune system recognize and fight back foreign microorganisms and inner modifications
that lead to deficient cell and tissue functions. During a dog's life, the immune system needs …

Phenotypic and functional differentiation of porcine αβ T cells: current knowledge and available tools

W Gerner, SC Talker, HC Koinig, C Sedlak, KH Mair… - Molecular …, 2015 - Elsevier
Domestic pigs are considered as a valuable large animal model because of their close
relation to humans in regard to anatomy, genetics and physiology. This includes their …

Porcine cytokines

MP Murtaugh - Veterinary immunology and immunopathology, 1994 - Elsevier
Cytokines play a central role in modulation of immunological and physiological processes in
animals under both homeostatic and abnormal conditions. Currently available information …

Advances in porcine genomics and proteomics—a toolbox for developing the pig as a model organism for molecular biomedical research

E Bendixen, M Danielsen, K Larsen… - Briefings in functional …, 2010 - academic.oup.com
Our current knowledge of human biology is often based on studying a wide range of animal
species. In particular, for understanding human diseases, the development of adequate …

[HTML][HTML] Efficacy of the porcine species in biomedical research

K Gutierrez, N Dicks, WG Glanzner, LB Agellon… - Frontiers in …, 2015 - frontiersin.org
Since domestication, pigs have been used extensively in agriculture and kept as companion
animals. More recently they have been used in biomedical research, given they share many …