Visceral pain is a highly complex experience and is the most common pathological feature
in patients suffering from inflammatory gastrointestinal disorders. Whilst it is increasingly …

Stress can trigger symptoms in patients with irritable bowel syndrome (IBS). Previously we
demonstrated that chronic psychological stress induced microglial remodeling in the central …

Crohn's disease (CD) and ulcerative colitis (UC) are incurable lifelong inflammatory bowel
diseases (IBD) with a rising worldwide incidence. IBD is characterized by diarrhea, rectal …

Inflammatory bowel disease (IBD) is a relapsing-remitting disorder characterized by chronic
inflammation of the gastrointestinal (GI) tract. Anxiety symptoms are commonly observed in …

Gastrointestinal disorders with abdominal pain are associated with central sensitization and
psychopathologies that are often exacerbated by stress. Here we investigated the impact of …

Visceral hypersensitivity is a common characteristic in patients suffering from irritable bowel
syndrome (IBS) and other disorders with visceral pain. Although the pathogenesis of visceral …

Cognitive behavioral therapy (CBT) improves the quality of life for patients with brain-gut
disorders; however, the underlying mechanisms of CBT remain to be explored. Previously …

Unlike physiological stress, which carries survival value, pathological stress is widespread
in modern society and acts as a main risk factor for visceral pain. As the main stress …

Background & Aims: We have identified that the anterior cingulate cortex (ACC) neurons are
responsive to colorectal distention (CRD) and shown that sensitization of ACC neurons …

Most gastrointestinal diseases and disorders (GIDD) are associated with depression,
anxiety, and cognitive dysfunction. This suggests that shared features of GIDD, particularly …