The two most frequently observed single nucleotide polymorphisms (SNPs) of the human
multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no …

Two representative genetic variants of the MDR1 gene, 3435C> T and 2677G> T/A, show
wide interethnic differences in its genetic polymorphism. In this study, the authors evaluated …

The MDR1 multidrug transporter plays a key role in determining drug bioavailability, and
differences in drug response exist amongst different ethnic groups. Numerous studies have …

The multi-drug resistant transporter MDR1/P-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette (ABC) …

There exists a marked inter-individual variability of P-glycoprotein expression and activity,
which can be of clinical importance due to the large number of drugs that are substrates for …

The human multidrug resistance gene (MDR1), spanning greater than 200 kb, encodes for
the ATP-dependent membrane efflux transporter, P-glycoprotein (Pgp). Significant progress …

The MDR1 multidrug transporter represents one of the better characterized drug transporters
that play an important role in protecting the body against xenobiotic insults. Single …

Background P‐glycoprotein, the gene product of MDR1, confers multidrug resistance
against antineoplastic agents but also plays an important role in the bioavailability of …

Drug transporters are increasingly recognized to be important to drug disposition and
response. P‐glycoprotein, the encoded product of the human MDR1 (ABCB1) gene, is of …

Background P‐glycoprotein is a transmembrane efflux pump that extrudes a wide variety of
drugs, thereby reducing their intracellular access. In humans, P‐glycoprotein is encoded by …