Importance Major depression (MD) aggregates within families, but how family history of MD
confers risk of MD over the life course is unclear. Such knowledge is important to identify …

Background Major depression (MD) is both clinically and etiologically heterogeneous. We
attempt to relate clinical and etiologic heterogeneity by determining those features of MD …

BackgroundStudies on the stability of genetic risk for depression have relied on self-reported
symptoms rather than diagnoses and/or short follow-up time. Our aim is to determine to what …

Importance Early-onset major depressive disorder (MDD) is common in individuals at high
familial risk of depression and is associated with poor long-term mental health, social, and …

OBJECTIVE: The authors conducted a meta-analysis of relevant data from primary studies of
the genetic epidemiology of major depression. METHOD: The authors searched MEDLINE …

Importance The increased risk of major depression in the offspring of depressed parents is
well known. Whether the risk is transmitted beyond 2 generations is less well known. To our …

BackgroundThis study seeks to clarify the contribution of temporally stable and occasion-
specific genetic and environmental influences on risk for major depression (MD). MethodOur …

Background Women report higher rates of major depression (MD) than men. Although
genetic factors play an important etiologic role in MD, we are uncertain whether genetic …

Importance Although the usefulness of polygenic risk scores as a measure of genetic liability
for major depression (MD) has been established, their association with depression in the …

Importance Combining information on polygenic risk scores (PRSs) with other known risk
factors could potentially improve the identification of risk of depression in the general …