Introduction: Ketamine has emerged as a rapid-acting antidepressant. While ongoing
treatment can prevent relapse, concerns exist regarding long-term exposure. Objective: We …

Introduction: Ketamine has shown rapid though short-lived antidepressant effects. The
possibility of concerning neurobiological changes following repeated exposure to the drug …

Background Several studies indicate that ketamine has rapid antidepressant effects in
patients with treatment-resistant depression (TRD). The extent to which repeated doses of …

Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …

Background Little is known about the antidepressive effects of repeated intravenous
ketamine infusions beyond the acute phase of treatment in patients with refractory …

Objective: Ketamine has demonstrated rapid antidepressant effects in patients with
treatment-resistant depression (TRD); however, the safety and tolerability of ketamine in this …

Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …

Introduction Ketamine treatment is capable of significant and rapid symptom improvement in
adults with treatment-resistant depression (TRD). A limitation of ketamine treatment in TRD …

Purpose The aim of the study was to assess the effectiveness, tolerability, and safety of oral
ketamine as an antidepressant treatment in adults with treatment-resistant depression …

Background Ketamine has been showing high efficacy and rapid antidepressant effect.
However, studies of ketamine infusion wash subjects out from prior antidepressants, which …