Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary
cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial …

Chronic pruritus is a burdensome feature of numerous hepatobiliary disorders such as
primary biliary cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, inherited forms …

Cholestasis, a condition characterized by an abnormal decrease in bile flow, is
accompanied by various symptoms such as pruritus. Although cholestatic pruritus is a …

Pruritus is an enigmatic, seriously disabling symptom accompanying cholestatic liver
diseases and a broad range of other disorders. Most recently, novel itchspecificneuronal …

Pruritus is frequently reported by patients with cholestatic hepatobiliary diseases such as
primary biliary cirrhosis, primary sclerosing cholangitis, intrahepatic cholestasis of …

Pruritus is a troublesome complication of chronic liver disease and often occurs in those with
cholestasis. It is commonly encountered and well recognized in chronic cholestatic …

Cholestasis is defined as impaired secretion of bile. 1 Pruritus is a complication of
cholestasis including that associated with mutations in genes that code for transporters in …

Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the
quality of life of those affected. Here, we provide an update on the latest insights into the …

Pruritus (itch) is an important symptom of primary biliary cirrhosis (PBC), an archetypal
cholestatic liver disease. Cholestatic pruritus can be a debilitating symptom causing …

Abstract Purpose of Review Chronic pruritus represents a burdensome symptom in
cholestatic liver disease. This review recommends a stepwise therapeutic approach …