Background Traxoprodil, a substituted 4-phenylpiperidine, is an N-methyl-D-aspartate
(NMDA) receptor antagonist that is selective for receptors containing the NR2B subunit. In …

Topiroxostat, a selective xanthine oxidoreductase inhibitor, is used in Japan for the
treatment of hyperuricemic patients with or without gout. In terms of the effectiveness of …

Vonoprazan is characterized as having a long-lasting antisecretory effect on gastric acid. In
this study we developed a physiologically based pharmacokinetic (PBPK) …

The genetic determinants of the allopurinol dose‐concentration relationship have not been
extensively studied. We aimed to clarify what factors, including genetic variation in urate …

Background Febuxostat is a novel non‐purine selective inhibitor of xanthine oxidase (NP‐
SIXO) being developed for the management of hyperuricemia in patients with gout. Aim The …

Background: Propylthiouracil (PTU) treats hyperthyroidism and thyroid crisis in all age
groups. A variety of serious adverse effects can occur during clinical use and require …

The concomitant administration of ritonavir and oxycodone may significantly increase the
plasma concentrations of oxycodone. This study was aimed to simulate DDI between …

GDC‐0810 was under development as an oral anti‐cancer drug for the treatment of
estrogen receptor‐positive breast cancer as a single agent or in combination. In vitro data …

Introduction: Patients with gout often have comorbid conditions such as renal failure,
cardiovascular disease and metabolic syndrome. The presence and required treatment of …

Piroxicam is a non-steroidal anti-inflammatory drug used to alleviate symptoms of
osteoarthritis and rheumatoid arthritis. CYP2C9 genetic polymorphism significantly …