Before 1990, the multiplicity of dopamine receptors beyond D1 and D2 had remained a
controversial concept, despite its substantial clinical implications, at a time when it was …

Dopamine is a major neurotransmitter in the central nervous system. Receptors for this
catecholamine are of considerable interest, as they are the principal target of drugs …

The behavioral and pathophysiological role of the dopamine D3 receptor, which was
deduced from anatomical, lesion and drug treatment studies in the ten years following …

The advances in molecular biology in the last decade have provided new insights into the
mechanisms of various diseases via the isolation and cloning of subtypes of G-protein …

The dopamine hypothesis of schizophrenia states that hyperactivity of the dopamine
neurotransmitter system underlies the symptoms of schizophrenia. Conventional neuroleptic …

The role of the D3 receptor has remained largely elusive before the development of
selective research tools, such as selective radioligands, antibodies, various highly specific …

Dopamine is an important neurotransmitter involved in motor control, endocrine function,
reward, cognition and emotion. Dopamine receptors belong to the superfamily of G protein …

Dopamine D 3 receptors have a pre-and postsynaptic localization in brain stem nuclei,
limbic parts of the striatum, and cortex. Their widespread influence on dopamine release, on …

The D3 receptor is recognized with high affinity by all antipsychotics and selectively
expressed in limbic brain areas participating in the central of emotions, motivation and …

The cloning of the gene for the D3 receptor and subsequent identification of its distribution in
brain and pharmacology allowed for serious consideration of the possibility that it might be a …