Development and validation of a biofidelic head form model to assess blast-induced traumatic brain injury

D Downes, A Bouamoul, S Ouellet… - The Journal of …, 2018 - journals.sagepub.com
Traumatic Blast Injury (TBI) associated with the human head is caused by exposure to a
blast loading, resulting in decreased level of consciousness, skull fracture, lesions, or death …

[HTML][HTML] A novel rat model of blast-induced traumatic brain injury simulating different damage degree: implications for morphological, neurological, and biomarker …

M Liu, C Zhang, W Liu, P Luo, L Zhang… - Frontiers in cellular …, 2015 - frontiersin.org
In current military conflicts and civilian terrorism, blast-induced traumatic brain injury (bTBI)
is the primary cause of neurotrauma. However, the effects and mechanisms of bTBI are …

The simple model versus the super model: translating experimental traumatic brain injury research to the bedside

KD Statler, LW Jenkins, CE Dixon, RSB Clark… - Journal of …, 2001 - liebertpub.com
Despite considerable investigation in rodent models of traumatic brain injury (TBI), no novel
therapy has been successfully translated from bench to bedside. Although well-described …

Blast-induced biomechanical loading of the rat: an experimental and anatomically accurate computational blast injury model

A Sundaramurthy, A Alai, S Ganpule… - Journal of …, 2012 - liebertpub.com
Blast waves generated by improvised explosive devices (IEDs) cause traumatic brain injury
(TBI) in soldiers and civilians. In vivo animal models that use shock tubes are extensively …

Effects of blast-induced neurotrauma on pressurized rodent middle cerebral arteries

UA Rodriguez, Y Zeng, MA Parsley… - JoVE (Journal of …, 2019 - jove.com
Though there have been studies on the histopathological and behavioral effects of blast
exposure, fewer have been dedicated to blast's cerebral vascular effects. Impact (ie, non …

Injury biomechanics, neuropathology, and simplified physics of explosive blast and impact mild traumatic brain injury

FA Bandak, G Ling, A Bandak… - Handbook of clinical …, 2015 - Elsevier
Explosive blast shock waves and blunt impact to the head are two types of loading shown to
result in mild traumatic brain injury (mTBI). While mTBI from these two causes shares some …

Biomechanics of blast TBI with time-resolved consecutive primary, secondary, and tertiary loads

A Przekwas, HT Garimella, XG Tan, ZJ Chen… - Military …, 2019 - academic.oup.com
Blast-induced traumatic brain injury (bTBI) has become a signature casualty of recent
military operations. In spite of significant clinical and preclinical TBI research, current …

Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from …

X Zhu, X Chu, H Wang, Z Liao, H Xiang, W Zhao… - Experimental …, 2024 - Elsevier
The utilization of explosives and chemicals has resulted in a rise in blast-induced traumatic
brain injury (bTBI) in recent times. However, there is a dearth of diagnostic biomarkers and …

Mechanics of blast loading on the head models in the study of traumatic brain injury using experimental and computational approaches

S Ganpule, A Alai, E Plougonven… - … and modeling in …, 2013 - Springer
Blast waves generated by improvised explosive devices can cause mild, moderate to severe
traumatic brain injury in soldiers and civilians. To understand the interactions of blast waves …

Blast physics and central nervous system injury

DF Moore, RA Radovitzky, L Shupenko, A Klinoff… - 2008 - Future Medicine
The effect of blast on biological tissue is well documented for particular organ systems such
as the lung. This is not the case for the CNS, where the mechanism of CNS injury following a …