Two unique HLA-A* 0201 restricted peptides derived from cyclin E as immunotherapeutic targets in leukemia

H He, Y Kondo, K Ishiyama, G Alatrash, S Lu, K Cox… - Leukemia, 2020 - nature.com
Immunotherapy targeting leukemia-associated antigens has shown promising results.
Because of the heterogeneity of leukemia, vaccines with a single peptide have elicited only …

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

S Ochsenreither, R Majeti, T Schmitt… - Blood, The Journal …, 2012 - ashpublications.org
Targeted T-cell therapy is a potentially less toxic strategy than allogeneic stem cell
transplantation for providing a cytotoxic antileukemic response to eliminate leukemic stem …

Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors

RS Andersen, RB Sørensen, C Ritter, IM Svane… - Cancer immunology …, 2011 - Springer
With the aim to identify cyclin B1-derived peptides with high affinity for HLA-A2, we used
three in silico prediction algorithms to screen the protein sequence for possible HLA-A2 …

Peptide vaccination elicits leukemia-associated antigen-specific cytotoxic CD8+ T-cell responses in patients with chronic lymphocytic leukemia

K Giannopoulos, A Dmoszynska, M Kowal, J Rolinski… - Leukemia, 2010 - nature.com
The receptor for hyaluronic acid-mediated motility (RHAMM) is a tumor-associated antigen
in chronic lymphocytic leukemia (CLL). CD8+ T cells primed with the RHAMM-derived …

Cyclin D1 as a universally expressed mantle cell lymphoma-associated tumor antigen for immunotherapy

M Wang, L Sun, J Qian, X Han, L Zhang, P Lin, Z Cai… - Leukemia, 2009 - nature.com
Mantle cell lymphoma (MCL) accounts for 5–10% of all non-Hodgkin lymphomas and has
the worst prognosis among all lymphomas. The hallmark of MCL is at (11; 14) translocation …

Cyclin-dependent kinaselike 5 is a novel target of immunotherapy in adult T-cell leukemia

M Kawahara, T Hori, Y Matsubara… - Journal of …, 2007 - journals.lww.com
In the present study, we attempted a comprehensive analysis of human leukocyte antigen
(HLA) class I-bound peptides presented on adult T-cell leukemia (ATL) cells by the latest …

Identification of a human cyclin D1-derived peptide that induces human cytotoxic CD4 T cells

T Dao, T Korontsvit, V Zakhaleva, K Haro, J Packin… - PloS one, 2009 - journals.plos.org
Cyclin D1 is over-expressed in various human tumors and therefore can be a potential
oncogenic target antigen. However, only a limited number of T cell epitopes has been …

Cancer testis antigen Cyclin A1 harbors several HLA-A* 02: 01-restricted T cell epitopes, which are presented and recognized in vivo

AT Teck, S Urban, P Quass, A Nelde… - Cancer Immunology …, 2020 - Springer
Cyclin A1 is a promising antigen for T cell therapy being selectively expressed in high-grade
ovarian cancer (OC) and acute myeloid leukemia (AML) stem cells. For adoptive T cell …

Cyclin D1–Specific Cytotoxic T Lymphocytes Are Present in the Repertoire of Cancer Patients: Implications for Cancer Immunotherapy

E Kondo, B Maecker, MR Weihrauch… - Clinical Cancer …, 2008 - AACR
Purpose: Cyclin D1, a key cell cycle regulator, is overexpressed in multiple types of cancer.
Such tumor-associated genes may be useful targets for cancer immunotherapy …

The shared tumor associated antigen cyclin‐A2 is recognized by high‐avidity T‐cells

E Kondo, B Maecker, A Draube… - … journal of cancer, 2009 - Wiley Online Library
Cyclin‐A2, a key cell cycle regulator, has been shown to be overexpressed in various types
of malignancies with little expression in normal tissue. Such tumor‐associated genes …