Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

D Olmeda, D Cerezo-Wallis, E Castellano-Sanz… - Advanced Drug Delivery …, 2021 - Elsevier
Imaging of the lymphatic vasculature has gained great attention in various fields, not only
because lymphatic vessels act as a key draining system in the body, but also for their …

[HTML][HTML] Nanoparticles for lymph node-directed delivery

J Lee, S Kang, H Park, JG Sun, EC Kim, G Shim - Pharmaceutics, 2023 - mdpi.com
Lymph nodes are organs that control immune cells and provide a major pathway for primary
tumors to metastasize. A nanoparticles-based strategy has several advantages that make it …

Advances in lymphatic imaging and drug delivery

SK Nune, P Gunda, BK Majeti, PK Thallapally… - Advanced drug delivery …, 2011 - Elsevier
Cancer remains the second leading cause of death after heart disease in the US. While
metastasized cancers such as breast, prostate, and colon are incurable, before their distant …

[HTML][HTML] Lymphatic drug delivery: therapy, imaging and nanotechnology

MS Cohen, ML Forrest - Advanced drug delivery reviews, 2011 - ncbi.nlm.nih.gov
The lymphatic system represents a relatively untapped biological highway to deliver
targeted drug molecules, nanoparticle drug-conjugates, imaging agents, vaccines and gene …

[HTML][HTML] Imaging technology of the lymphatic system

AK Polomska, ST Proulx - Advanced drug delivery reviews, 2021 - Elsevier
The lymphatic system plays critical roles in tissue fluid homeostasis and immunity and has
been implicated in the development of many different pathologies, ranging from …

Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery

ST Proulx, P Luciani, LC Dieterich, S Karaman… - Journal of controlled …, 2013 - Elsevier
Over the last 15 years, discovery of key growth factors and specific molecular markers for
lymphatic vessels has enabled a new era of molecular research on the lymphatic vascular …

Overcoming physiological barriers by nanoparticles for intravenous drug delivery to the lymph nodes

N Trac, EJ Chung - Experimental Biology and Medicine, 2021 - journals.sagepub.com
The lymph nodes are major sites of cancer metastasis and immune activity, and thus
represent important clinical targets. Although not as well-studied compared to subcutaneous …

Nano-sized drug delivery systems for lymphatic delivery

HY Cho, YB Lee - Journal of Nanoscience and …, 2014 - ingentaconnect.com
The lymphatic system plays important roles for immune responses, spreading cancer cells or
viruses and disseminating infections. Thus, targeting drugs, such as anticancer …

Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors

B Cote, D Rao, RG Alany, GS Kwon… - Advanced Drug Delivery …, 2019 - Elsevier
Although many solid tumors use the lymphatic system to metastasize, there are few
treatment options that directly target cancer present in the lymphatic system, and those that …

[HTML][HTML] The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery

S Qi, X Wang, K Chang, W Shen, G Yu, J Du - Journal of …, 2022 - Springer
Lymphatic system is identified the second vascular system after the blood circulation in
mammalian species, however the research on lymphatic system has long been hampered …