Oxidative stress (OS) is one of the major pathomechanisms of Alzheimer's disease (AD),
which is closely associated with other key events in neurodegeneration such as …

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …

Alzheimer's disease (AD) is a tragic, progressive, age-related neurological dysfunction,
representing one of the most prevalent neurodegenerative disorders in industrialized …

Abstract Currently, 5.4 million Americans suffer from AD, and these numbers are expected to
increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have …

RNA oxidation and its biological effects are less well studied compared to DNA oxidation.
However, RNA may be more susceptible to oxidative insults than DNA, for RNA is largely …

Oxidative stress plays a critical role in the etiology and pathogenesis of Alzheimer's disease
(AD), and the molecular mechanisms that control the neuron response to oxidative stress …

Pathology of Alzheimer's disease (AD) goes far beyond neurotoxicity resulting from
extracellular deposition of amyloid β (Aβ) plaques. Aberrant cleavage of amyloid precursor …

Two of the main research priorities in the United States are cancer and neurodegenerative
diseases, which are attributed to abnormal patterns of cellular behavior. MicroRNAs …

Cytoplasmic RNA oxidation is a prominent feature of vulnerable neurons in the brains of
Alzheimer's disease (AD) patients. We previously demonstrated that messenger RNAs …