Preterm infants are at particularly high risk for infectious diseases. As this vulnerability
extends beyond the neonatal period into childhood and adolescence, preterm infants benefit …

Infections take their greatest toll in early life necessitating robust approaches to protect the
very young. Here, we review the rationale, current state, and future research directions for …

Infancy and childhood are critical life stages for generating immune memory to protect
against pathogens; however, the timing, location, and pathways for memory development in …

Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …

All neonates, infants and young children receive multiple priming doses and booster
vaccinations in the 1st and 2nd year of life to prevent infections by viral and bacterial …

Newborns, especially those born preterm, are at high risk for infection. Preterm birth rates
appear to be increasing in most countries, with∼ 15 million infants born preterm globally …

The conception of how the immune system is operational has been significantly better
understood in recent years. One critical finding is the recognition that lymphocytes are not …

Essentially, all neonates are exposed to infections, antibiotics, or vaccines early in their
lives. This is especially true for those neonates born underweight or premature. In contrast to …

Immunisation of the newborn represents a key global strategy in overcoming morbidity and
mortality due to infection in early life. Potential limitations, however, include poor …

Preclinical and human vaccine studies indicate that, although neonatal immunisation does
not generally lead to rapid and strong antibody responses, it may result in an efficient …