Rho kinase (ROCK) belongs to a family of Ser/Thr protein kinases that are activated via
interaction with the small GTP-binding protein RhoA. Growing evidence suggests that RhoA …

There is growing evidence that Rho-kinases (ROCKs), the immediate downstream targets of
the small guanosine triphosphate-binding protein Rho, may contribute to cardiovascular …

The Rho/rho-kinase (ROCK) pathway has an important role in the pathogenesis of several
cardiovascular diseases. The activation of ROCK is involved in the regulation of vascular …

RhoA and Rho-kinase (ROCK) participate in diverse cellular signaling functions such as
smooth muscle contraction, cytoskeleton rearrangement, and cell migration and …

Rho kinase (ROCK) is a major downstream effector of the small GTPase RhoA. ROCK
family, consisting of ROCK1 and ROCK2, plays central roles in the organization of actin …

Highlights•Rho kinase signaling plays important roles in the cardiovascular system.•Rho
kinase signaling mediates cardiac hypertrophy, apoptosis and fibrosis.•Rho kinase signaling …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as
downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various …

Rho-kinase (ROCK) is one of the effectors of the small GTP-binding protein Rho.
Accumulating evidence suggests that the Rho/ROCK system may play an important role in …

Rho-kinase (ROCK) is one of the downstream effectors of the small G-protein Rho. The Rho–
ROCK pathway has an important role in mediating various cellular functions, including …

Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein
RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have …